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A.V. Syroeshkin Dr.Sc. (Biol.), Professor, Head of Department of Pharmaceutical and Toxicological Chemistry, RUDN University Institute of Medicine (Moscow) Е-mail: M.P. Makarova Post-graduate student, Department of Pharmaceutical and Toxicological Chemistry, RUDN University Institute of Medicine (Moscow) T.V. Maksimova Ph.D. (Pharm.), Associate Professor, Department of Pharmaceutical and Toxicological Chemistry, RUDN University Institute of Medicine (Moscow) T.V. Pleteneva Dr.Sc. (Chem.), Professor, Department of Pharmaceutical and Toxicological Chemistry, RUDN University Institute of Medicine (Moscow)

Objective. To develop the basics of technology for obtaining new elements modified plant products that can be used for hypoelementoses correction. Materials and methods. Water samples: deionized highohmic water (BD, D/H=140 ppm); deuterium depleted water (DDW, D/H=12 ppm); me-dicinal and nonoficinal plants (leaves and seeds). Atomic absorption spectrometry with electrothermal atomization and Zeeman effect; Xray fluorescence energy dispersive spectrometr; Low-Angle Laser Light Scattering, LALLS); Spirotox-test equipment. OriginPro®9, OriginLab Corporation, USA. Results. For the first time, the integrated approach was used to develop the technology fundamentals for plant accumulation by essential micro-elements. The approach includes isotopic control of plant development; new laser methods for quality control of water solutions for plants irrigation and hydroponics; the methods for the control of microelements enrichment of plant materials; online control of biotoxicity (Spirotox test) of the original plant materials and modified plants. For example, it has been demonstrated the ability to create zinc (II) modified plants with a high content of essential trace elements, up to 1.4 mg / g dry weight, which corresponds to zinc content increase by three orders of magnitude. Conclusion. Plant materials enriched with essential microelements can be recommended as the objects for the creation of the medicinal products that do not cause undesirable side effects, in contrast to the synthetic preparations used for the correction of hypoelementoses.

zinc-deficient states
kinetic isotope effect
medicinal and food plants

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