DOI: https://doi.org/10.29296/25877313-2020-04-03
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V.A. Kutyakov Ph.D. (Biol.), Associate Professor, Department of Biological Chemistry with a course in medical, pharmaceutical and toxicological chemistry, Krasnoyarsk State Medical University named after Professor V.F. Voyno-Yasenetsky E-mail: victor-koutjakov@yandex.ru K.A. Dmitrieva Student, Krasnoyarsk State Medical University named after Professor V.F. Voyno-Yasenetsky E-mail: kira.dmitrieva.17@bk.ru

Relevance. The use of non-steroidal anti-inflammatory drugs (NSAIDs) is not limited to medical indications. Drugs are often used to relieve pain in drug addiction, so they are often found during forensic analysis along with psychoactive substances. The identification and measurement of the con-centration of any toxicants is important for establishing a causal relationship between their use and harm to health or death. Purposes of the work: to identify the use of NSAIDs by different groups of consumers; determination of the possibility of using these drugs as indirect markers of the use of controlled substances; establishing a correlation between the joint detection of NSAIDs and controlled substances; comparison of detected concentrations of substances with therapeutic, toxic, lethal concentrations. The research material was the results of the work of the forensic chemical department of the Krasnoyarsk Bureau of Forensic Medical Examination for 2016-2018. Biological material research methods included liquid-liquid extraction of compounds from objects, gas chromatography with mass spectral detection after derivatization. The results of forensic chemical studies were processed and interpreted using factor, regression, and correlation analysis methods. Results. Data were obtained on the age-sex characteristics of NSAIDs consumers, a positive correlation between the use of NSAIDs and controlled substances, the range of concentrations of NSAIDs in cadaveric blood was determined. Conclusions. An increase in the detection of NSAIDs during forensic chemical studies was revealed. The main consumers of this group of medicines are persons aged 31 to 45 years; the number of male consumers prevails over women. Detection of NSAIDs in biological fluids of cadavers and a strong positive correlation may serve as markers of possible intravital use of controlled substances. Excess toxic concentrations of NSAIDs in cadaver-ic blood was recorded in 0.33% of cases, typical only for ibuprofen and ketorolac.Key words: forensic chemical analysis, non-steroidal anti-inflammatory drugs, controlled substances, use marker, correlation.

forensic chemical analysis
non-steroidal anti-inflammatory drugs
controlled substances
use marker

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  1. Badoskin V.V. Slozhnosti vyubora optimalnogo nesteroidnogo protivospalitelnogo preparata: v fokuse meloksikam. RMZH. Meditsinskoe obozrenie. 2016; 26:17721776.
  2. Davis J.S., Lee H.Y., Kim J., Advani S.M., Peng H.-L., Banfield E., Hawk E.T., Chang S., Frazier-Wood A.C. Use of non-steroidal anti-inflammatory drugs in US adults: changes over time and by demographic. Open Heart. 2017; 4(1):e000550.
  3. Ahuja M., Dhake A.S., Sharma S.K., Majumdar D.K. Topical ocular delivery of NSAIDs. An Official Journal of the American Association of Pharmaceutical Scientists. 2008; 10(2):229–241.Доступно: https://pubs.niaaa.nih.gov/publications/Medici-ne/medicine.htm. Дата обращения - 24.06.2019 г.
  4. Dhondt L., Devreese M., Croubels S., De Baere S., Haesendonck R., Goessens T., Gehring R., De Backer P., Antonissen G. Comparative population pharmacokinetics and absolute oral bioavailability of COX-2 selective inhibitors celecoxib, mavacoxib and meloxicam in cockatiels (Nymphicushollandicus). International Journal of Scientific Reports. 2017; 7(1): 12043.
  5. Ma L., Mao X., Sun X., Xu L. Biotransformation of NSAIDs by pig liver microsomes in vitro: Kinetics, metabolites identification and toxicity prediction. Chemosphere. 2017; 186:466–474.
  6. Blazaki S., Tsika C., Tzatzarakis M., Naoumidi E., Tsatsakis A., Tsatsanis C., Tsilimbaris M.K. Pharmacokinetics and efficacy of intraocular flurbiprofen. Graefe's Archive for Clinical and Experimental Ophthalmology. 2017; 255(12):2375–2380.
  7. Dvorskaya O.N., Kataev S.S., Silina T.A., Krokhin I.P. Otsenka kontsentratsii nekotorykh nesteroidnyukh protivovospolitelnyukh sredstv v protsedure skrininga lekarstvennyukh i narkoticheskikh veshshestv v krovi. Sudebno-meditsinskaya ekspertiza. 2016; 3:24–30.
  8. Dvorskaya O.N., Kataev S.S., Krokhin I.P. Opredelenie ryada nesteroidnogo protivovospalitelnyukh sredstv v krovi v skrininge metodami tverdofaznyumi ekstraktsii i gazovoi khromotografii s mass-spektrometricheskim detektirovaniem. Butlerovskie soobshcheniya. 2015; 43(7):149153.
  9. Kutyakov V.A., Nemikhin V.V., Kachin S.V. Opredelenie etorikoksiba metodom vyusokoeffektivnoi zhidkostnoi khromotografii. Voprosyu biologicheskoi, meditsinskoi i farmatsevticheskoi khimii. 2019; 22(5):4752.
  10. Prikaz Minzdravsotsrazvitiya RF ot 12 maya 2010 g. N 346 n. «Ob utverzhdenii poryadka organizastii i proizvodstva sudebno-meditsinskikh ekspertiz v gosudarstvennyukh uchrezhdeniyakh Rossiiskoi Federastii». Dostupno: https://www.drugbank.ca. Data obrashcheniya – 24.06.2019 g.
  11. Petukhova N.N., Malkova T.L., Salomatin E.M. Obnaruzhenie i kolichestvennoe opredelenie ketorolaka dlya tselei khimiko-toksilogicheskogo analiza. Informatsionnoe pismo. 2011. С. 31.
  12. TIAFT reference blood level list of therapeutic and toxic substances. September, 2004.