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RELATIONSHIP BETWEEN SERUM METAL AND METALLOID LEVELS WITH METABOLIC RISK MARKERS IN OVERWEIGHT AND OBESE WOMEN

DOI: https://doi.org/10.29296/25877313-2020-05-04
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Issue: 
5
Year: 
2020

A.A. Tinkov Ph.D. (Med.), Research Scientist, Yaroslavl State University (Yaroslavl); Leader Research Scientist, Sechenov University; Peoples’ Friendship University of Russia (Moscow) E-mail: tinkov.a.a@gmail.com O.P. Ajsuvakova Ph.D. (Chem.), Research Scientist, Yaroslavl State University (Yaroslavl) M.G. Skalnaya Dr.Sc. (Med.), Professor, Chief Research Scientist, Sechenov University (Moscow) A.V. Skalny Dr.Sc. (Med.), Professor, Head of Laboratory, Yaroslavl State University; Head of Laboratory, Sechenov University (Moscow); Head of Department, Yaroslavl State University (Yaroslavl)

The objective of the present study was to assess serum metal and metalloid levels in patients with overweight and obesity, as well as evaluation of its association with metabolic risk markers. Material and methods. A total of 82 adult women with overweight and obesity (BMI > 25), as well as 88 lean (18.5 < BMI < 25) controls were ex-amined. Assessment of serum metal levels was performed using inductively-coupled plasma mass-spectrometry. Serum was also used for evalua-tion of markers of lipid and carbohydrate metabolism, as well as inflammation and oxidative stress. Results. The obtained data demonstrate that patients with obesity were characterized by at herogenic dyslipidemia, insulin resistance, systemic in-flammation, as well as oxidative stress. A significant increase in alanine aminotransferase, γ-glutamyl transferase, and cholinesterase activity was observed. Serum copper and aluminium levels in overweight and obese subjects exceeded the control values by 12% and 17%, respectively. Copper concentration was also considered as a positive predictor of increased BMI (β=0.391; p=0.008) in regression models, being also negatively interrelated with total antioxidant activity (β=0.322; p=0.032) and high-density lipoprotein cholesterol (β=0.241; p=0.024) after adjustment for anthropometric parameters. At the same time, serum vanadium (β=0.576; p=0.027) and chromium (β=0.682; p=0.036) were inversely associated with fasting glu-cose concentration. Zinc level was considered as the most significant predictor of total antioxidant activity (β=0.643; p=0.003). Conclusion. Therefore, serum metal and metalloid levels in patients with obesity are associated with pathogenetic mechanisms of metabolic syn-drome including insulinresistance, at herogenic dyslipidemia, inflammation, and oxidative stress.
Keywords: 
copper
aluminium
metabolic syndrome
insulin resistance
dyslipidemia

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