EXCIPIENTS FOR USE IN MEDICATED CHEWING GUM TECHNOLOGY

DOI: https://doi.org/10.29296/25877313-2020-06-01
Issue: 
6
Year: 
2020

K.V. Alekseev Dr.Sc. (Pharm.), Professor, Chief Research Scientist, the Laboratory of Finished Dosage Forms, Federal State Budget Scientific Institution «Scientific Research Institute of Pharmacology named after V.V. Zakusova» (Moscow) E.V. Blynskaya Dr.Sc. (Pharm.), Head of the Laboratory of Finished Dosage Forms, Experimental and Technological Department, Federal State Budget Scientific Institution «Scientific Research Institute of Pharmacology named after V.V. Zakusova» (Moscow) S.V. Tishkov Research Scientist, the Laboratory of Finished Dosage Forms, Experimental and Technological Department, Federal State Budget Scientific Institution «Scientific Research Institute of Pharmacology named after V.V. Zakusova» (Moscow) E-mail: sergey-tishkov@ya.ru V.V. Bueva Junior Research Scientist, Federal State Budget Scientific Institution «Scientific Research Institute of Pharmacology named after V.V. Zakusova» (Moscow) A.A. Ivanov Engineer, Federal State Budget Scientific Institution «Scientific Research Institute of Pharmacology named after V.V. Zakusova» (Moscow)

Chewing gum medicines are a dosage form having unique characteristics such as elasticity, plastic deformation, chewing, optimal organoleptic properties and the release of pharmaceutical substance only during chewing. The shown properties of chewing gum medications are provided by a combination of various auxiliary substances, some of which are characteristic for obtaining these dosage forms. For example, the use of combinations of insoluble and soluble components: elastomers (Jelutong, Chicle, isobutylene and isoprene copolymers, etc.), polyvinyl acetate, texturants (magnesium and calcium carbonates, titanium oxide, etc.), plasticizers (terpene resins , lecithin, etc.), emulsifiers, sweeteners (sorbitol, xylitol, aspartame, potassium acesulfame, etc.), waxes, dyes, flavors, antioxidants, lubricants and glidants. The article presents a modern classification of excipients used for chewing gum medicinal products according to their functional purpose, discloses the features of the use of auxiliary substances in the technology for producing chewing gum medicinal products. In addition, various aspects of the use of the presented individual excipients, complex excipients and excipients that perform certain specific functions to modify release, etc. are described. The article presents a large number of examples of many classes of auxiliary substances used, includes basic ratios, mass fractions of components, primary and additional functional purpose, as well as technological aspects of their use. New directions of searching and improving the formulations of chewing gum medicines, for example, the development of biodegradable bases, the use of ion-exchange resins and cyclodextrins, have been reflected. Features of the use of some flavorings explains the aspects of taste masking depending on the pharmaceutical substance. A correlation was made between the ratio of components and the structural-mechanical, textural properties of the dosage form, such as chewing, hardness, stickiness, adhesion to the tooth surface, as well as the release of a pharmaceutical substance. The conclusion is drawn about the features of application, prospects and development trends of modern excipients for chewing gum medicinal.

Keywords: 
Chewing gum medicinal
excipients
elastomers
plasticizers
sweeteners

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