INFLUENCE OF THE RHAPONTICUM UNIFLORUM DRY EXTRACT ON THE BEHAVIOR OF WHITE RATS IN POSITIVE SUPPORTED TESTS

DOI: https://doi.org/10.29296/25877313-2020-11-05
Issue: 
11
Year: 
2020

Ya.G. Razuvaeva Dr.Sc. (Biol.), Senior Research Scientist, Institute of General and Experimental Biology SB RAS (Ulan-Ude) E-mail: tatur75@mail.ru K.V. Markova Post-graduate Student, Banzarov Buryat State University (Ulan-Ude) A.A. Toropova Ph.D. (Biol.), Research Scientist, Institute of General and Experimental Biology SB RAS (Ulan-Ude) D.N. Olennikov Dr.Sc. (Pharm.), Senior Research Scientist, Institute of General and Experimental Biology SB RAS (Ulan-Ude)

The purpose: of the study was to evaluate the Rhaponticum uniflorum L. DC. dry extract on the white rats behavior in positive supported tests. Material and methods: The studies were carried out on white Wistar rats. The R. uniflorum dry extract in the doses 50, 100 and 200 mg/kg was administered (per os) to animals experimental groups. The amount of food ingested by the animals was measured in the hyponeophagia test. The food-procuring conditioned reflex was formed in a T-shaped labyrinth. Results. It was found that 63-88% of the animals ate food under unfamiliar conditions in the experimental groups, while in the control group only 38%. The food-procuring conditioned reflex was formed in 29 and 38% of animals treated with R. uniflorum at doses of 100 and 200 mg/kg, whereas in the control group, no animal reached the learning criterion. Against the background of the introduction of the R. uniflorum at a dose of 50 mg/kg, food-procuring conditioned reflex developed in 71% of the animals of the first experimental group. Conclusions. The R. uniflorum dry extract has an anxiolytic-like effect, promoting the adaptation of animals to unfamiliar conditions and increasing the amount of food in the hyponeophagia test, as well as faster development of the food-procuring conditioned reflexe in the T-shaped labyrinth.

Keywords: 
Rhaponticum uniflorum L. DC. (Fornicium uniflorum (L.) Zuev.)
dry extract
hyponeophagia test
food-procuring conditioned reflex

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