Нажмите на эту строку чтобы перейти к Новостям сайта "Русский врач"

Перейти
на сайт
журнала
"Врач"
Перейти на сайт журнала "Медицинская сестра"
Перейти на сайт журнала "Фармация"
Перейти на сайт журнала "Молекулярная медицина"
Перейти на сайт журнала "Вопросы биологической, медицинской и фармацевтической химии"
Журнал включен в российские и международные библиотечные и реферативные базы данных

ВАК (Россия)
РИНЦ (Россия)
Эко-Вектор (Россия)

STANDARDIZATION OF MEDICINAL DRUG WITH ORIGINAL SUBSTANCE OF BENZOPHENONE DERIVATIVE FOR HIV-1 INFECTION TREATMENT

DOI: https://doi.org/10.29296/25877313-2021-01-01
Download full text PDF
Issue: 
1
Year: 
2021

V.M. Kosman Ph.D. (Pharm.), St.-Petersburg Institute of Pharmacy (Russian Federation, Leningrad region, Vsevolozhski municipal district, Kuzmolovo) E-mail: kosmanvm@ doclinika.ru E.A. Jain (Korsakova) Post-graduate Student, Lomonosov Moscow State University, Faculty of Medicine (Russian Federation, Moscow) D.V. Demchenko Ph.D. (Pharm.), St.-Petersburg Institute of Pharmacy (Russian Federation, Leningrad region, Vsevolozhski municipal district, Kuzmolovo) V.G. Makarov Dr.Sc. (Med.), Professor, RMC “HOME OF PHARMACY” (Russian Federation, Leningrad region, Vsevolozhski municipal district, Kuzmolovo) E-mail: info@doclinika.ru V.Y. Balabanyan Dr.Sc. (Pharm.), Lomonosov Moscow State University, Faculty of Medicine (Russian Federation, Moscow)

Synthetic pyrimidine derivative of benzophenone 1-[2-(2-benzoylphenoxy)ethyl]-6-methyluracil was proposed as an original pharmaceutical substance for the development of antiretroviral drugs. The aim of the study was to develop and validate methods for qualitative and quantitative standardization of the drug dosage form (tablets) with the original pharmaceutical substance of the benzophenone derivative for the treatment of HIV-1 infection. Material and methods. Experimental tablets were obtained in laboratory conditions of RMC “HOME OF PHARMACY” (Russia) in accordance with laboratory guidelines and analyzed by various pharmacopoeia methods. Results. In order to evaluate the identification and quantify the active substance in the drug high-performance liquid chromatography with UV detection was proposed, acceptance criteria for quality control were established, methods were validated according to modern requirements and met them in all parameters. To assess the tablets quality tests on the characteristics of appearance, average weight and uniformity in weight, abrasion, disintegration, excipients (aerosil) were proposed. Conclusion. Methods of standardization based on HPLC with UV-detection for dosage form with original pharmaceutical substance based on benzophe-none derivative for treatment of HIV-1 infection were proposed and validated.
Keywords: 
tablets
original substance
benzophenone derivative
standardization

It appears your Web browser is not configured to display PDF files. Download adobe Acrobat или click here to download the PDF file.

References: 
  1. Lagunin A.A., Filimonov D.A., Glorizova T.A. i dr. Virtual'nyj skrining v bibliotekah kommercheski dostupnyh organicheskih soedinenij potencial'nyh sredstv dlja pro-filaktiki VICh-infekcij. HFZh. 2013; 47(7): 3–21.
  2. Pechinskij S.V., Kuregjan A.G., Ozerov A.A., Novikov M.S. Dizajn novyh proizvodnyh uracila, obladajushhih ingibitornoj aktivnost'ju v otnoshenii obratnoj transkrip-tazy mutanta K103N/Y181C VICh-1. HFZh. 2015; 49(10): 40–43.
  3. Rostova N.B., Ivanova Je.S., Gudilina N.A., Kiseleva O.V. Antiretrovirusnaja terapija: podhody k lecheniju i real'naja praktika naznachenij pri lechenii vich-inficirovannyh pacientov. Medicinskij al'manah. 2016; 1(41): 112–116.
  4. Chabria S.B., Gupta S., Kozal M.J. Deep sequencing of HIV: clinical and research applications. Annual review of genomics and human genetics. 2014; 15: 295–325.
  5. Ozerov A., Novikov M., Khandazhinskaya A., Solyev P. Selective n¹-alkylation of 1, 3-dibenzoyluracils: one-pot way to n¹-monosubstituted uracil derivatives. Heter-ocycles: an international journal for reviews and communications in heterocyclic chemistry. 2017; 94(5): 912–922.
  6. Novikov M.S., Ivanova O.N., Ivanov A.V., Valuev-Elliston V.T., Temburnikar K., Ozerov A.A., Gurskaya G.V., Kochetkov S.N., Pannecouque C., Balzarini J., Seley-Radtke K.L. 1-[2-(2-Benzoyl- and 2-benzylphenoxy)ethyl]uracils as potent anti-HIV-1 agents. Bioorg. Med. Chem. 2011; 19: 5794–5902.
  7. Ozerov A.A., Novikov M.S., Luganchenko A.I., Hartman T., Bukhajt R.U. Novye N-[2-(Benzoilfenoksi)jetil]proizvodnye nukleinovyh osnovanij – sintez i anti-VICh-1 aktivnost' in vitro. Volgogradskij nauchno-medicinskij zhurnal 2012; 4: 15–18.
  8. Makarov V.G., Makarova M.N., Demchenko D.V., avtory; AO «NPO «DOM FARMACII», patentoobladatel'. Sposoby povyshenija rastvorimosti lekarstvennogo sredstva na osnove pirimidinovogo proizvodnogo benzofenona. Patent RF 2729792. 12.08.2020
  9. Kosman V.M., Obluchinskaja E.D., Pozharickaja O.N., Shikov A.N. Skvoznaja standartizacija substancii fukoidana iz fukusa puzyrchatogo Fucus vesiculosis L. i pre-paratov na ee osnove. Farmacija. 2017; 66(6): 20–24.
  10. Gosudarstvennaja Farmakopeja Rossijskoj Federacii. HIV izd. M.: MZ RF. 2018; T.1–4: 7019 s.
  11. Rukovodstvo po validacii analiticheskih metodik provedenija ispytanij lekarstvennyh sredstv. Utv. pesheniem kollegii stran EJeK ot 17.07.2018 № 113. 2018: 26 s.
  12. Rukovodstvo po validacii metodik analiza lekarstvennyh sredstv. M.: Ministerstvo zdravoohranenija i social'nogo razvitija RF. 2007: 49 s.