MULTICOMPONENT MEDICINAL PREPARATIONS: ADVANTAGES OF THEIR USE IN CLINICAL PRACTICE

DOI: https://doi.org/10.29296/25877313-2021-02-01
Issue: 
2
Year: 
2021

S.M. Nikolaev Dr.Sc. (Med.), Professor, Chief Research Scientist of the Laboratory of Experimental Pharmacology, Institute of General and Experimental Biology SB RAS; Professor of the Department of Pharmacology and Traditional Medicine, Medical institute, Buryat State University named after Dorzhi Banzarov (Ulan-Ude) E-mail: smnikolaev@mail.ru L.N. Shantanova Dr.Sc. (Biol.), Professor, Head of the Laboratory of Biologically Active Substances Safety, Institute of General and Experimental Biology SB RAS; Professor of the Department of Human Anatomy and Physiology, Medical Institute, Buryat State University named after Dorzhi Banzarov (Ulan-Ude) E-mail: shantanova@mail.ru V.B. Khobrakova Dr.Sc. (Biol.), Associate Professor, Head of the Laboratory of Experimental Pharmacology, Institute of General and Experimental Biology SB RAS; Professor of the Department of Human General Pathology, Medical Institute, Buryat State University named after Dorzhi Banzarov (Ulan-Ude) E-mail: val0808@mail.ru Ya.G. Razuvaeva Dr.Sc. (Biol.), Leading Research Scientist of Laboratory of Biologically Active Substances Safety, Institute of General and Experimental Biology SB RAS; Senior Lecturer of the Department of Human Anatomy and Physiology, Medical Institute, Buryat State University named after Dorzhi Banzarov (Ulan-Ude) E-mail: tatur75@mail.ru S.A. Chukaev Ph.D. (Med.), Associate Professor, Senior Lecturer of the Department of Pharmacology and Traditional Medicine, Medical Institute, Buryat State University named after Dorzhi Banzarov (Ulan-Ude) E-mail: s_chukaev@mail.ru V.E. Khitrikheev Dr.Sc. (Med.), Professor, Head of the Department of Hospital Surgery, Medical Institute, Buryat State University named after Dorzhi Banzarov (Ulan-Ude) E-mail: khitrikheev-ve@yandex.ru

The prospects of the use of multicomponent preparations in clinical practice are discussed on the base of the analysis of formularies. Today, many diseases are caused by stress, improper lifestyles associated with hypodynamic, impaired nutrition, and environmental distress. In this situation, it is necessary to regulate pharmacotherapy with complex drugs at the systemic level, which provides correction along the hierarchical ladder of life pro-cess management, mobilization of internal reserves for maintaining health, interfacing the action of the ingredients of the complex with the functional systems of the patient. In folk medicine of many countries, traditional eastern medicine, for thousands of years, multi-component (complex, com-bined, complex) drugs have been used, containing several ingredients, two or more active pharmacological substances. The inclusion of a number of medicinal components in one ready-made dosage form creates great amenities for the patient, eliminating the need to take many separate drugs, ob-serving the order of their use, and experiencing inconvenience in the treatment and prevention of the disease. From the point of view of evidence-based medicine, they have withstood millennial trials, they have laid down centuries of experience in their successful use, and today, it is, multicom-ponent drugs of traditional medicine that are most interesting for research. The expressed effectiveness of the combined preparation is due to potenti-ation of the action of ingredients with unidirectional activity, but with different mechanisms. By reducing the proportion of components in the complex, the risk of undesirable effects when taken is reduced. Small doses of the components of the complex preparation allow modulating the natural pro-cesses of health restoration, accompanying the action of the main substances and creating conditions for the manifestation of the activity of the ac-companying elements of the complex. The studies have shown that the complex drugs have a number of advantages: ease of use; drug potentiation; risk reduction of side effects; costs reduction; system effect of the complex as pharmacotherapeutic system. The emphasis is laid on the traditional combined remedies as their efficacy and safety have been proved for thousands of years and they are of great interest at present time.

Keywords: 
multicomponent preparations
one-component preparations
efficacy and safety
advantages of complex remedies
pharmacothera-peutical system

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