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GROWTH FACTOR OF VESSEL ENDOTHELIUM IN NEW CORONAVIRAL DISEASE – 2019 (COVID-19) COMPLICATED WITH PNEUMONIA

DOI: https://doi.org/10.29296/25877313-2021-06-01
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Issue: 
6
Year: 
2021

I.T. Murkamilov Ph.D. (Med.), Acting Associate Professor of the Department of faculty therapy of Kyrgyz State Medical Academy named after I.K. Akhunbaev; Senior Lecturer, Kyrgyz-Russian Slavic University, Nephrologist, Chairman of the board of Chronic Kidney Disease Specialists Society of Kyrgyzstan (Bishkek, Kyrgyzstan) ORCID:0000-0001-8513-9279 E-mail: murkamilov.i@mail.ru I.S. Sabirov Dr.Sc. (Med.), Professor, Head of the Department of Therapy № 2, SEIHPE Kyrgyz-Russian Slavic University, board member of Chronic Kidney Disease Specialists Society of Kyrgyzstan (Bishkek, Kyrgyzstan) ORCID: 0000-0002-8387-5800 E-mail: sabirov_is@mail.ru V.V. Fomin Dr.Sc. (Med.), Professor, Corresponding Member of RAS, Head of the Department of Faculty Therapy № 1, Sklifosovsky Institute; Vice-rector in Clinical Work and continuous Professional Education, I.M. Sechenov First Moscow State Medical University (Sechenov University) of the Ministry of Healthcare of Russia (Moscow, Russia) ORCID: 0000-0002-2682-4417 E-mail: fomin@mma.ru I.O. Kudaibergenova Dr.Sc. (Med.), Professor,Rector of the Kyrgyz State Medical Academy named after I.K. Akhunbaev (Bishkek, Kyrgyzstan) ORCID: 0000-0003-3007-8127 E-mail: k_i_o2403@mail.ru Zh.A. Murkamilova Post-graduate Student, the Department of Therapy № 2, SEIHPE Kyrgyz-Russian Slavic University (Bishkek, Kyrgyzstan) ORCID:0000-0002-7653-0433 E-mail:murkamilovazh.t@mail.ru F.A. Yusupov Dr.Sc. (Med.), Professor, Head of the Department of Neurology, Neurosurgery and Psychiatry, Medicinal Faculty, Osh State University, Board Member of Chronic Kidney Disease Specialists Society of Kyrgyzstan; Chief Neurologist of Southern Region of Kyrgyzstan (Osh, Kyrgyzstan) ORCID: 0000-0003-0632-6653

The aim of the study is to study the vascular endothelial growth factor in the new coronavirus disease – 2019 (COVID-19). Material and methods.The object of the study is patients (36 men and 28 women, mean age 48.9 ± 15.3 years) with laboratory and clinical and ep-idemiologically confirmed diagnosis of COVID-19, complicated by pneumonia. The indicators of peripheral and biochemical blood were analyzed. Serum levels of vascular endothelial growth factor (VEGF) concentration were assessed by quantitative enzyme-linked immunosorbent assay. The patients were divided into 2 groups depending on gender (men, n = 36 (56.25%); women, n = 28 (43.75%) and the degree of blood oxygen saturation (group A, n = 26 (40.62 %) SaO2 level below 90%; group B, n = 38 (59.38%) SaO2 level above 90%). Results. In the subgroup of men with COVID-19 complicated by pneumonia, significantly low levels of hemoglobin (Hb) oxygen saturation, lymphocyte counts, as well as high levels of leukocytes and blood creatinine were detected.The content of Hb and the average concentration of Hb in erythrocytes (MHC) were significantly lower among women with COVID-19 complicated by pneumonia. In a subgroup of men, there was a significant increase in VEGF concentration. A close relationship was recorded between concentration of VEGF and SatO2 (r = -0.341, p = 0.019), average Hb content in eryth-rocyte (MCH) (r = -0.201, p = 0.045), relative number of lymphocytes (r = -0.362, p = 0.018), distribution width erythrocytes (r = 0.381, p = 0.010), the number of platelets (r = 0.503, p = 0.007), erythrocyte sedimentation rate (ESR) (r = 0.555, p = 0.001), as well as with the concentration of C-reactive protein (CRP) (r = 0.394, p = 0.005). Conclusion. The VEGF concentration correlates with the indices of Hb oxygen saturation, the number of platelets, the relative number of lymphocytes, the width of distribution of erythrocytes, ESR, MCH, as well as the level of CRP in the blood. The predictor of the severity of COVID-19 in men was the level of oxygen saturation, the number of leukocytes, the relative number of lymphocytes and blood creatinine, and in females - additionally also the level of Hb and the MCHS indicator.
Keywords: 
COVID-19
pneumonia
vascular endothelial growth factor
erythrocyte morphology
hypoxia
endothelium

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