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ASSESSMENT OF THE HEPATOTOXIC POTENTIAL OF ORGANOTIN COMPOUNDS CONTAINING 2,6-DI-TERT-BUTYLPHENOL FRAGMENT

DOI: https://doi.org/10.29296/25877313-2021-08-03
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Issue: 
8
Year: 
2021

M.A. Dodokhova Ph.D. (Med.), Associate Professor, Department of Biomedicine and Neuroscience, and General and Clinical Biochemistry No. 2, Rostov State Medical University (Rostov-on-Don, Russia) E-mail: dodohova@mail.ru A.V. Safronenko Dr.Sc. (Med.), Professor, Department of Pharmacology and Clinical Pharmacology, Rostov State Medical University (Rostov-on-Don, Russia) E-mail: andrejsaf@mail.ru I.M. Kotieva Dr.Sc. (Med.), Professor, Department of Pathological Physiology, Rostov State Medical University (Rostov-on-Don, Russia) E-mail: kukulik70@mail.ru E.R. Milaeva Dr.Sc. (Chem.), Professor, Department of Medicinal Chemistry and Fine Organic Synthesis, Lomonosov Moscow State University (Moscow, Russia) E-mail: milaeva@med.chem.msu.ru D.B. Shpakovsky Ph.D. (Chem.), Senior Researcher, Department of Medicinal Chemistry and Fine Organic Synthesis, Lomonosov Moscow State University (Moscow, Russia) E-mail: dmshpak@mail.ru Yu.M. Makarenko Ph.D. (Med.), Pathologic and Anatomical Bureau of the Russian Academy of Sciences (Rostov-on-Don, Russia) E-mail: markovich1962@yandex.ru V.G. Trepel Ph.D. (Med.), Rostov-on-Don branch of the Federal State Budgetary Institution "IMCEUAOSMP" of Roszdravnadzor (Rostov-on-Don, Russia) E-mail: vartantrepel.61@gmail.com M.S. Alkhuseyn-Kulyaginova Senior Laboratory Assistant, Department of Chemistry, Rostov State Medical University (Rostov-on-Don, Russia) Е-mail: rita.kuljaginva@rambler.ru

The article is devoted to the in vivo study of the effect of organotin compounds containing 2,6-di-tert-butylphenol fragment on liver morpho-functional state. The aim of this study was to evaluate the biochemical and histological changes in the liver with a single intragastric administration of bis (3,5-di-tert-butyl-4-hydroxyphenylthiolate) dimethyltin (Me3) and (3,5-di-tert-butyl-4-hydroxyphenylthiolate) triphenyltin (Me5) to Wistar rats (female) at the maximum tolerated dose (MTD) of 2000 mg/kg and 750 mg/kg, respectively. It was found that the introduction of Me3 and Me5 do not cause significant structural changes in liver, and the disorders are of a functional nature. The results of this work allow us to conclude that the hepatotoxicity of organotin compounds containing 2,6-di-tert-butylphenol is low, which opens up broad prospects for studying these compounds as candidates for antitumor drugs.
Keywords: 
organotin compounds
hepatotoxicity
medicinal liver damage
antitumor drugs

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