THE INFLUENCE OF DRY EXTRACT POTENTILLA ALBA L. ON THE GENERATIVE FUNCTION OF FEMALE RATS

Relevance. Currently, thyroid diseases have a high social significance, which is determined by a significant increase in their prevalence, large financial costs for diagnosis and treatment. In this regard, the active search for new medicines with a thyroprotective effect continues. Of particular interest are medicinal plants that serve as a source of biologically active substances that affect the main mechanisms of the development of the disease. Such plants include Potentilla alba L., from the roots and rhizomes of which, in the Research institute of medicinal and aromatic plants, a dry extract with a thyrotropic effect was obtained. Due to the fact that one of the mandatory stages of preclinical studies of new pharmacological substances is the study of their effect on the generative function of laboratory animals, it was relevant to study the effect of the dry extract Potentilla alba L. on the ability of female rats to conceive. The aim of the study was to study the effect of the dry extract on the generative function of female experimental rats and their offspring in the pre - and postnatal period of development. Material and Methods. The choice of methods for studying the effect of the dry extract Potentilla alba L. on the generative function of female rats was determined by the requirements set out in the "Guidelines for conducting preclinical studies of medicines". Experiments were performed on male and female Wistar rats weighing 180-200 g (female) and 200-240 g (male). In this study, the test extract was introduced to female rats in the stomach for 15 days at doses of 25 and 125 mg/kg. After the end of the introduction period, the experimental females were mated with intact males. The control animals were intact females and males crossed with each other. The resulting pregnant females were divided into two groups. In the first group of female rats on the 20th day of pregnancy, the number of corpus luteum, positions of implantation, resorptions, live and dead fetuses was calculated, pre-and post-implantation death was calculated; the fetuses were subjected to external examination. From female rats of the other group, offspring were obtained, in which the dynamics of changes in body weight and death before the end of the feeding period (21 days) were taken into account, the rate of maturation of sensory-motor reflexes was determined, and the functional state of the central nervous system was studied according to oriented reactions in the "open field" test. Results. As a result of the experiment, it was found that the introduction of dry extract Potentilla alba L. to female rats in the tested doses before mating with intact males did not affect their ability to conceive. The studied extract did not have a negative effect on the ante - and postnatal development of the offspring of female rats that received the extract before mating with intact males. Conclusion. The dry extract Potentilla alba L. with prolonged introduction into the stomach of female rats in doses exceeding the therapeutic 5 and 15 times, did not affect their generative function and indicators of physical development of the offspring