DIPEPTIDE BDNF MIMETIC GSB-106 PREVENTS DEPRESSION-LIKE BEHAVIOR AND COGNITIVE IMPAIRMENT CAUSED BY ISCHEMIC STROKE IN RATS

DOI: https://doi.org/10.29296/25877313-2022-02-08
Issue: 
2
Year: 
2022

P.Yu. Povarnina Ph.D. (Biol.), FSBI «Zakusov Institute of Pharmacology» (Moscow, Russia) E-mail: povarnina@gmail.com D.M. Nikiforov Ph.D. (Biol.), FSBI «Zakusov Institute of Pharmacology» (Moscow, Russia) O.N. Vorontsova Ph.D. (Biol.), FSBI «Zakusov Institute of Pharmacology» (Moscow, Russia) T.A. Gudasheva Ph.D. (Biol.), Professor, Member-corr. of RAS, FSBI «Zakusov Institute of Pharmacology» (Moscow, Russia)

Relevance. Depression and cognitive impairment are common complications of acute cerebrovascular accidents. Disorders of hippocampal neuro-plasticity associated with a decrease in BDNF expression are considered as one of the causes of these complications. A dimeric dipeptide mimetic of the BDNF loop 4, (bis (N-monosuccinyl-L-seryl-L-lysine) hexamethylenediamide) (GSB-106) was created at the V.V. Zakusov Research Institute of Pharmacology. GSB-106 demonstrated antidepressant, neuroprotective and neuroregenerative properties in in vivo experiments. Objective. Experiments were performed on 40 male rats Wistar weighing 240–280 g. Purpose of the study is to investigate the effect of GSB-106 on depression-like behavior and memory impairments in rats induced by middle cerebral artery occlusion (MCAO). Material and methods. GSB-106 was injected intraperitoneally at a dose of 0.1 mg/kg for 21 days after surgery. Depressive-like behavior was de-tected in the forced swimming test, and memory impairments – in the novel object recognition test. Conclusions. GSB-106 is a promising compound for further development as a drug for the treatment of post-stroke depression and cognitive impair-ment.

Keywords: 
dipeptide mimetic
BDNF
GSB-106
experimental stroke
depression
memory

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