Нажмите на эту строку чтобы перейти к Новостям сайта "Русский врач"

Перейти
на сайт
журнала
"Врач"
Перейти на сайт журнала "Медицинская сестра"
Перейти на сайт журнала "Фармация"
Перейти на сайт журнала "Молекулярная медицина"
Перейти на сайт журнала "Вопросы биологической, медицинской и фармацевтической химии"
Журнал включен в российские и международные библиотечные и реферативные базы данных

ВАК (Россия)
РИНЦ (Россия)
Эко-Вектор (Россия)

INULIN AS A COMPONENT OF FORTIFIED FOODSTUFFS: INFLUENCE ON THE MICRONUTRIENT STATUS

DOI: https://doi.org/10.29296/25877313-2022-03-05
Download full text PDF
Issue: 
3
Year: 
2022

V.M. Kodentsova Dr.Sc. (Biol.), Professor, Federal Research Centre of Nutrition, Biotechnology and Food Safety (Moscow, Russia) ORCID 0000-0002-5288-1132 E-mail: kodentsova@ion.ru S.N. Leonenko Posr-graduate Student, Federal Research Centre of Nutrition, Biotechnology and Food Safety (Moscow, Russia) ORCID0000-0003-0048-4220 N.A. Beketova Ph.D. (Chem.), Senior Research Scientist, Federal Research Centre of Nutrition, Biotechnology and Food Safety (Moscow, Russia) ORCID0000-0003-2810-2351 O.V. Kosheleva Research Scientist, Federal Research Centre of Nutrition, Biotechnology and Food Safety (Moscow, Russia) ORCID0000-0003-2391-9880 O.A. Vrzhesinskaya Ph.D. (Biol.), Senior Research Scientist, Federal Research Centre of Nutrition, Biotechnology and Food Safety (Moscow, Russia) ORCID 0000-0002-8973-8153 A.A. Sokolnikov Ph.D. (Biol.), Senior Research Scientist, Federal Research Centre of Nutrition, Biotechnology and Food Safety (Moscow, Russia) ORCID0000-0003-1808-652X L.V. Shevyakova Ph.D. (Biol.), Senior Research Scientist, Federal Research Centre of Nutrition, Biotechnology and Food Safety (Moscow, Russia) ORCID0000-0002-7447-8520 D.V. Risnik Ph.D. (Biol.), Leading Research Scientist, Federal Research Centre of Nutrition, Biotechnology and Food Safety (Moscow, Russia) ORCID0000-0002-3389-8115

Relevance. Inulin is used as a source of polyfructosans in specialty foods for preventive nutrition to reduce the risk of chronic diseases. Along with the proven positive effect on the intestinal microbiota, the absorption of calcium, magnesium and zinc, data on the negative impact on the supply with vitamin E are emerging. The aim of the study was to evaluate the effect of introducing inulin into the diet on the assimilation of micronutrients in growing rats deficient in vit-amins D and group B. Material and methods. To assess the effect of inulin on the micronutrient status of growing male Wistar rats (body weight 51.4 ± 0.5 g) in a semisynthetic diet deficient in vitamins D and group B for 7 days the missing vitamins were introduced with or without inulin enrich-ment of the diet (5%). The indices of micronutrient status were compared with the parameters of rats adequately provided with all vitamins throughout the experiment. The content of calcium and iron in the freeze-dried liver and brain was determined on a Z 5300 atomic absorption spectrophotometer (Hitachi High-Technologies Corporation (HHC), Japan), biochemical parameters of blood and urine were determined on a KoneLab 200i biochemical ana-lyzer (ThermoScientific, Finland). Results. The presence of inulin in the diet slowed down the restoration of the normal supply with vitamins B1 and B6 (urine excretion), B2 (content in the brain), and also led to a 1.4-fold increase of the liver iron concentration, while simultaneously decreasing the con-centration of liver vitamin E compared with the control group. Conclusions. Against the background of the existing multiple vitamin deficiency, the simultaneous presence of inulin and vitamins in the diet does not guarantee the complete absorption of all added vitamins and may lead to undesirable consequences. The effectiveness of n fortified product or dietary supplement for correcting the vitamin and mineral status may significantly depend on the composition of the product, which indicates the need for their clinical testing, confirming the bioavailability of the fortifying components and their effectiveness for maintaining health.

Keywords: 
multiple deficiency of vitamins D and B group
inulin
correction
α-tocopherol
iron
rats

It appears your Web browser is not configured to display PDF files. Download adobe Acrobat или click here to download the PDF file.

References: 
  1. Pilipenko V.I., Morozov S.V., Isakov V.A. Dietoterapija sindroma razdrazhennogo kishechnika s problemami za-porov s ispol'zovaniem specializirovannogo pish-hevogo produkta dieticheskogo lechebnogo pitanija «koncentrat kiselja s vitaminami i inulinom «Intenorm». Dokazatel'naja gastrojenterologija. 2018; 7(4): 92106.
  2. Hiel S., Bindels L.B., Pachikian B.D., Kalala G., Broers V., Zamariola, G., Chang B.P.I., Kambashi B., Rodriguez J., Cani P.D., Neyrinck A.M., Thissen J.P., Luminet O., Bindelle J., Delzenne N.M. Effects of a diet based on inulinrich vegetables on gut health and nutritional behavior in healthy humans. Am. J. Clin. Nutr. 2019; 109(6): 16831695. doi: 10.1093/ajcn/nqz001.
  3. Pandey K.R., Naik S.R., Vakil B.V. Probiotics, prebiotics and synbiotics – a review. J. Food Sci. Technol. 2015; 52(12): 75777587. doi: 10.1007/s13197-015-1921-1.
  4. Miles J.P., Zou J., Kumar M.V., Pellizzon M., Ulman E., Ricci M., Chassaing B. Supplementation of Low- and High-fat Diets with Fermentable Fiber Exacerbates Severity of DSS-induced Acute Colitis. Inflamm. Bowel. Dis. 2017; 23: 11331143. doi: 10.1097/MIB.0000000000001155.
  5. Vrzhesinskaja O.A., Kodencova V.M., Sharafetdinov H.H., Beketova N.A., Kosheleva O.V., Plotnikova O.A., Pilipen-ko V.V., Alekseeva R.I., Leonenko S.N., Sokol'ni-kov A.A. Vlijanie priema napitka s vitaminami i pishhevymi voloknami na vitaminnyj status pacientov s saharnym diabetom 2 tipa i ozhireniem. Voprosy dietologii. 2018; 8(4): 512. doi: 10.20953/2224-5448-2018-4-5-12.
  6. Becerril-Alarcón Y., Campos-Góm, S., Valdez-Andrad, J.J., Campos-Gómez K.A., Reyes-Barretero D.Y., Benitez-Arci-niega A.D., Valdés-Ramos R., Soto-Piña A.E. Inulin supplementation reduces systolic blood pressure in women with breast cancer undergoing neoadjuvant chemotherapy. Cardiovasc Ther. 2019; 2019: 5707150. doi: 10.1155/2019/5707150.
  7. Zou J., Chassaing B., Singh V., Pellizzon M., Ricci M., Fyth M.D., Kumar V., Gewirtz A.T. Fiber-mediated nourishment of gut microbiota protects against diet-induced obesity by restoring IL-22-mediated colonic health. Cell host & microbe. 2018; 23(1): 4153. doi: 10.1016/j.chom.2017.11.003.
  8. Soldi S., Vasileiadis S., Lohner S., Uggeri F., Puglisi E., Molinari P., Donner E., Sieland C., Decsi T., Sailer M., Theis S. Prebiotic supplementation over a cold season and during antibiotic treatment specifically modulates the gut microbiota composition of 3-6 year-old children. Beneficial microbes. 2019; 10(3): 253263. doi: 10.3920/BM2018.0116.
  9. Drabińska N., Krupa-Kozak, U., Abramowicz P., Jarocka-Cyrta E. Beneficial effect of oligofructose-enriched inulin on vitamin D and E status in children with celiac disease on a long-term gluten-free diet: a preliminary randomized, placebo-controlled nutritional intervention study. Nutrients. 2018; 10(11): 1768. doi: 10.3390/nu10111768.
  10. Whisner C.M., Castillo L.F. Prebiotics, bone and mineral metabolism. Calcif Tissue Int. 2018; 102(4): 443479. doi: 10.1007/s00223-017-0339-3.
  11. Coudray C., Rambeau M., Feillet-Coudray C., Tressol J.C., Demigne C., Gueu E., Maz A., Rayssiguier Y. Dietary inulin intake and age can significantly affect intesti-nal absorption of calcium and magnesium in rats: a stable isotope approach. Nutrition Journal. 2005; 4(1): 29. doi: 10.1186/1475-2891-4-29.
  12. Raschka L., Daniel H. Diet composition and age determine the effects of inulin-type fructans on intestinal calcium absorption in rat. Eur. J. Nutr. 2005; 44(6): 360364. doi: 10.1007/s00394-004-0535-6.
  13. Scholz-Ahrens K.E., Schrezenmeir J. Inulin and oligofructose and mineral metabolism: the evidence from animal trials. J. Nutr. 2007; 137(11): 2513S2523S.
  14. Samolińska W., Grela E.R. Comparative effects of inulin with different polymerization degrees on growth performance, blood trace minerals, and erythrocyte indices in growing-finishing pigs. Biol Trace Elem Res. 2017; 176(1): 130142. doi: 10.1007/s12011-016-0796-y.
  15. Pauly M.J., Rohde J.K., John C., Evangelakos I., Ko A.C., Pertzborn P., Tödter K., Scheja L., Heeren J., Worthmann A. Inulin Supplementation Disturbs Hepatic Cho-lesterol and Bile Acid Metabolism Independent from Housing Temperature. Nutrients. 2020; 12(10): 3200. doi: 10.3390/nu12103200.
  16. Myhill L.J., Stolzenbach S., Mejer H., Jakobsen S.R., Hansen T.V., Andersen, D., Brix S., Hansen L.H., Krych L., Nielsen D.S., Nejsum P., Thamsborg S.M., Williams A.R. Fermentable dietary fiber promotes helminth infection and exacerbates host inflammatory responses. J. Immunol. 2020; 204(11): 30423055. doi: 10.4049/jimmunol.1901149.
  17. Mirmiran P., Bahadoran Z., Khalili Moghadam S., Zadeh Vakili A., Azizi F. A Prospective Study of different types of dietary fiber and risk of cardiovascular disease: Tehran lipid and glucose study. Nutrients. 2016; 8(11): E686. doi: 10.3390/nu8110686.
  18. Beketova N.A., Kodencova V.M., Vrzhesinskaja O.A., Kosheleva O.V., Pereverzeva O.G., Sokol'nikov A.A., Aksenov I.V. Korrekcija poligipovitaminoza u rastushhih krys razlich-nymi dozami vitaminov na fone obogashhennogo pishhevymi voloknami raciona. Voprosy pitanija. 2014; 83(4): 2941.
  19. Kodencova V.M., Leonenko S.N., Beketova N.A., Kosheleva O.V., Vrzhesinskaja O.A., Sokol'nikov A.A., Shevjakova L.V., Risnik D.V., Zorin S.N. Zavisimost' jeffek-tivnosti korrekcii deficita vitamina D i ego posledstvij u krys ot obespechennosti vitaminami gruppy V. Voprosy biologicheskoj, medicinskoj i farmacevticheskoj himii. 2021; 24(4): 410. doi: 10.29296/25877313-2021.
  20. Spirichev V.B., Kodencova V.M., Vrzhesinskaja O.A., Beketo-va N.A., Haritonchik L.A., Alekseeva I.A., Sokol'nikov A.A., Risnik V.V. Metody ocenki vitaminnoj obespechennosti naselenija. Ucheb.-metodich. Posobie. M.: PKC Al'teks, 2001; 68 s.
  21. Povoroznjuk V.V., Gopkalova I.V., Grigor'eva N.V. Osoben-nosti izmenenij mineral'noj plotnosti kostnoj tkani u belyh krys linii Vistar v zavisimosti ot vozrasta i pola. Problemy starenija i dolgoletija. 2011; 20(4): 393401.
  22. Koterov A.N., Ushenkova L.N., Zubenkova Je.S., Vajnson A.A., Birjukov A.P. Sootnoshenie vozrastov osnovnyh laborator-nyh zhivotnyh (myshej, krys, homjakov i sobak) i cheloveka: aktual'nost' dlja problemy vozrastnoj radiochuvstvitel'-nosti i analiz opublikovannyh dannyh. Medicinskaja ra-diologija i radiacionnaja bezopas-nost'. 2018; 63(1): 527.
  23. Kodencova V.M., Vrzhesinskaja O.A. Obespechennost' de-tej vodorastvorimymi vitaminami (20152018 gg.). Voprosy praktichekoj pediatrii. 2019; 14(2): 714. doi: 10.20953/1817-7646-2019-2-7-14.
  24. Verduci E., Giannì M.L., Vizzari G., Vizzuso S., Cerasani J., Mosca F., Zuccotti G.V. The triad mother-breast milk-infant as predictor of future health: a narrative re-view. Nutrients. 2021; 13(2): 486. doi: 10.3390/nu13020486.
  25. Beketova N.A., Kodencova V.M., Vrzhesinskaja O.A., Kosheleva O.V., Pereverzeva O.G., Isaeva V.A., Pozdnjakov A.L. Vlijanie pshenichnyh otrubej na obespechennost' organiz-ma vitaminami (jeksperiment na krysah). Voprosy pita-nija. 2011; 80(6): 3542.
  26. Pogozheva A.V., Kodencova V.M., Vrzhesinskaja O.A., Derbeneva S.A., Beketova N.A., Pereverzeva O.G., Kosheleva O.V. Vlijanie pishhevyh volokon na usvoenie vitaminov u bol'-nyh s serdechno-sosudistymi zabolevanijami i ozhireniem. Voprosy pitanija. 2010; 79(1): 3439.
  27. Kornen N.N., Viktorova E.P., Evdokimova O.V. Metodo-logicheskie podhody k sozdaniju produktov zdorovogo pi-tanija. Voprosy pitanija. 2015(1): 9599.
  28. Pilipenko V.I., Tepljuk D.A., Shahovskaja A.K., Isakov V.A., Vorob'eva V.M., Vorob'eva I.S., Glazkova I.V., Kochetkova A.A., Miheeva G.A., Judina A.V. Jeffek-tivnost' speciali-zirovannogo pishhevogo produkta (kiselja s vitaminami i pishhevymi voloknami) u bol'nyh s sindromom razdra-zhennogo kishechnika s zaporami: sravnitel'noe kontro-liruemoe issledovanie. Voprosy pitanija. 2015; 84(6): 8391.
  29. Kodencova V.M., Vrzhesinskaja O.A. Vitaminno-mineral'nye kompleksy: sootnoshenie doza  jeffekt. Voprosy pitanija. 2006; (1): 3039.
  30. Shih E.V., Solov'eva S.A., Perkov A.V. Sinergizm kompo-nentov kak osnovnoj podhod k formirovaniju probioticheskogo kompleksa. Medicinskij Sovet. 2020; (5): 120127.
  31. Kodencova V.M., Zhilinskaja N.V., Shpigel' B.I. Vitami-nologija: ot molekuljarnyh aspektov k tehnologijam vitaminizacii detskogo i vzroslogo naselenija. Voprosy pi-tanija. 2020; 89(4): 8999.