FEATURES OF THE COURSE OF METABOLIC PROCESSES IN THE BODY OF LABORATORY ANIMALS WITH ADDITIONAL FEEDING OF MANGANESE ASPARAGINATE

Manganese is an essential element, acting as a cofactor in the active centers of various enzymes, it is necessary for normal development, mainte-nance of the functions of the nervous system and immune cells, regulation of blood sugar and vitamins. The aim of the study is to evaluate the effect of additional administration of Mn asparaginate on changes in the dynamics of live weight, the devel-opment of internal organs and the exchange of chemical elements in the liver of laboratory animals. Material and methods. The studies were carried out in the conditions of the experimental biological clinic of the OSU on a model - male rats of the Wistar line weighing 110120 g, 80 heads. The animals were divided into 4 groups (n=20), the experimental groups received manganese asparaginate per os in dosages of 1 mg/kg, 2 mg/kg and 3 mg/kg. Results. It was found that with the additional use of Mn asparaginate in various dosages, a decrease in live weight was observed in animals of the experimental groups on the 14th day of the experimental study by 2.0% - 4.52% relative to the control values. A longer administration of this element (28 days), on the contrary, contributed to an increase in live weight relative to the control by 1.44%  5.52%. In rats under the influence of manganese asparaginate in all experimental groups receiving Mn at dosages of 2.0 mg/kg, 1.0 mg/kg, 3.0 mg/kg, an increase in heart and brain mass was observed by 10.45%, 4.76%, 11.76% and 3.75%, 8.33%, 3.14%, respectively. Conclusion. The exchange of chemical elements in the liver of laboratory animals showed that Mn asparaginate contributed to the elimination of most essential and conditionally essential elements, as well as macronutrients and, conversely, the accumulation of heavy metals in the liver.