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PHYSICAL, CHEMICAL AND TECHNOLOGICAL ASPECTS OF A GEL FOR ORAL ADMINISTRATION LYCOPUS EUROPAEUS L. HERB DRY EXTRACT

DOI: https://doi.org/10.29296/25877313-2022-09-03
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Issue: 
9
Year: 
2022

O.A. Semkina
Ph.D. (Pharm.), All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow, Russia)
E-mail:semkinaolga@gmail.com
V.I. Zvereva
Ph.D. (Pharm.), All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow, Russia)
M.A. Dzhavakhyan
Dr.Sc. (Pharm.), All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow, Russia)
N.P. Pavets
Post-graduate Student, All-Russian Scientific Research Institute of Medicinal and Aromatic Plants (Moscow, Russia)

Relevance. Modern trends in the development of medicines in the form of soft dosage forms are gels for oral administration. Their undoubted ad-vantages: convenience and ease of reception, high bioavailability of active substances, the possibility of use in pediatric and geriatric practice, as well as in patients suffering from dysphagia. Aim. Experimental substantiation of the choice of structure-forming substances of the gel for oral administration of the Lycopus europaeus L. herb dry extract. Material and methods: Lycopus europaeus L. herb dry extract standardized (the content of the sum of phenolic compounds in terms of rosemary acid is not less than 15%). Lycopus europaeus L. herb dry extract has an effect on the functional condition of the thyroid gland and can be used to ob-tain thyroid-stimulating drugs. The measurement of the viscosity of the gel samples was carried out in accordance with the method of General Phar-macopoeia XIV, Monograph 1.2.1.0015.15 "Viscosity". The determination of the pH value was carried out according to General Pharmacopoeia XIV, Monograph 1.2.1.0004.15 "Ionometry". Instruments and apparatus: Rotary viscometer "Reotest-2" type RV (Germany), mixing device PE-8100 (Ekros, Russia) at a speed of 100 rpm, pH-meter 121, analytical scales VLA-200-M. Results. The article presents the results of the development of a dosage form (DF) of Lycopus europaeus L. herb dry extract – a gel for oral admin-istration. Lycopus europaeus L. herb dry extract have an effect on the functional state of the thyroid gland and can be used to obtain thyroid-stimulating drugs. The choice of excipients was carried out taking into account the nosology, the method of administration of the drug, the physicochemical and technological properties of the substance, its compatibility with excipients. Conclusion. The structure of gel samples was studied by microscopy, the features of the technology of obtaining a gel for ingestion of Lycopus euro-paeus L. herb dry extract were substantiated.
Keywords: 
gel for oral administration
dry extract
rheological properties
herb of Lycopus europaeus L.
gel bases

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