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PREDICTION OF THE SPECTRUM OF BIOLOGICAL ACTIVITY OF TRITERPENE SAPONINS USING IN SILICO METHODS

DOI: https://doi.org/10.29296/25877313-2023-02-01
Issue: 
2
Year: 
2023

N.A. Davitavyan
Ph.D. (Pharm.), Associate Professor, Department of Pharmacy,
Kuban State Medical University (Krasnodar, Russia)
E-mail: farmdep@mail.ru
E.B. Nikiforova
Ph.D. (Pharm.), Associate Professor, Acting Head of the Department of Pharmacy,
Kuban State Medical University (Krasnodar, Russia)
B.K. Shkhalakhova
Student, Faculty of Pharmacy, Kuban State Medical University (Krasnodar, Russia)
D.A. Ismagilova
Assistant, Department of Pharmacy,
Kuban State Medical University (Krasnodar, Russia)

Relevance. The main strategic task of the domestic pharmaceutical industry is to provide the population of our country with affordable, high-quality, safe and effective medicines. At the same time, of particular interest for modern pharmacy is the creation of herbal medicines with a multifunctional effect and a high degree of safety. Plants of the Fabaceae family, the practical value of which is due to the rich chemical composition of biologically active substances, can be promising sources for obtaining phytopreparations. The triterpene saponins of plants of the Fabaceae family, which have a wide spectrum of pharmacological action, deserve special attention. The aim of the work was to study and predict the biological activity of triterpene saponins contained in plants of the Fabaceae family using in silico methods. Material and methods. The objects of study were the structural formulas of triterpene saponins from plants of the Fabaceae family. Prediction of the biological activity of triterpene saponins was carried out using in silico methods posted on the domestic web resource Way2Drug. Results. As a result of in silico studies, triterpene saponins demonstrated a high probability of hepatoprotective, proto-tumor, and anti-inflammatory effects. Along with this, at the level of the average value and below for the studied saponins, antibacterial effects were revealed. Conclusions. The data obtained on the basis of computer screening confirm, clarify and expand the available scientific information on the pharmacological effects of triterpene saponins from plants of the Fabaceae family. The prospects of carrying out further studies in vitro and in vivo with the aim of clarifying and/or confirming the types of activity of biologically active substances from the group of saponins identified in silico and the subsequent development of drugs based on them have been demonstrated.
Keywords: 
triterpene saponins
Fabaceae family
web resource Way2Drug
PASS-online
AntiBac Pred.
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