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CHARACTERISTICS OF THE AMINO ACID PROFILE OF BLOOD PLASMA IN PSORIASIS

DOI: https://doi.org/10.29296/25877313-2023-05-02
Issue: 
5
Year: 
2023

S.V. Kupriyanov
Post-graduate Student, Department of Biochemistry named after R.I. Lifshitz,
South Ural State Medical University (Chelyabinsk, Russia)
E-mail: pfft@mail.ru
Yu.M. Shatrova
Ph.D. (Biol.), Researcher, Research Institute of Immunology,
South Ural State Medical University (Chelyabinsk, Russia)
D.A. Sysakov
Ph.D. (Med.), Assistant of the Department of Dermatovenereology,
South Ural State Medical University (Chelyabinsk, Russia)
K.S. Fedorova
Senior Laboratory Assistant, Research Institute of Immunology,
South Ural State Medical University (Chelyabinsk, Russia)
D.E. Myakotina
Senior Laboratory Assistant, Research Institute of Immunology,
South Ural State Medical University (Chelyabinsk, Russia)
A.N. Kholina
transfusiologist, Head of the Department of Blood Procurement and its Components,
Chelyabinsk Regional Blood Transfusion Station (Chelyabinsk, Russia)
A.I. Sinitsky
Dr.Sc. (Med.), Associate Professor, Head of the Department of Biochemistry named after R.I. Lifshitz,
South Ural State Medical University (Chelyabinsk, Russia)

Introduction. Psoriasis is an autoimmune disease that affects the skin, has a number of systemic manifestations and is associated with the devel-opment of a number of somatic pathologies. It is known that one of the systemic features of psoriasis is changes in the blood plasma amino acid pool, but the pathogenetic significance of this fact has not yet been determined. The purpose of this work was to study the amino acid profile of blood plasma in psoriasis and its relationship with biochemical markers of lipid and purine metabolism. Materials and methods. The study group included 45 patients with psoriasis vulgaris. The comparison group included 46 donors of the Chelyabinsk Regional Blood Transfusion Station. The concentrations of 20 proteinogenic amino acids, as well as ornithine and citrulline, were determined. Results. Recorded changes demonstrating the rearrangement of relationships between the concentrations of circulating amino acids in psoriasis; cor-relations of amino acid levels with a number of clinical diagnostic biochemical markers in the group of patients with psoriasis were determined. A sig-nificant increase in the levels of cysteine, phenylalanine and leucine was found in psoriasis compared with the corresponding indicators of the compar-ison group. Cysteine concentrations positively correlated with uric acid levels. Elevated levels of cysteine and leucine have been associated with disor-ders of purine and lipid metabolism. Conclusions. The data obtained indicate changes in the amino acid profile in psoriasis, some of which may be associated with the development of comorbid metabolic pathologies.
Keywords: 
metabolomics
amino acids
psoriasis
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