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SPONTANEOUS PLATELET AGGREGATION AND IMMUNOCYTOKINES AND HORMONES INFLUENCE IN THYROID DYSFUNCTION
DOI: https://doi.org/10.29296/25877313-2019-01-02
Issue:
1
Year:
2019
The change of spontaneous aggregation (SA) was investigated and the influence of the immuncytokines level, the hormones of thyrotropic and free tetraiodthyronine in patients with hypothyroidism, non-toxic single/multinodular goiter and in patients with combined pathology (single/manynodular non-toxic goiter and hypothyroidism). The aim of our study was to study spontaneous aggregation and immunocytokine levels in patients with hypothyroidism, non-toxic sin-gle/multinodular goiter and in patients with combined pathology (single/manynodular non-toxic goiter and hypothyroidism). Results and conclusions. In patients with thyroid pathology there is a growth of SA reaching its maximum in patients with combined pathology. The concentration of immunocytokines (IL-6, TNF-α, IL-8, homocysteine) besides endoteline-1 in patients with hypothyroidism and combined pathology did not differ from the control. SA significantly correlates with IL-8, homocysteine and endoteline-1 due to the group. The level of SA does not depend on the hormone level (TTG and T4 free) and IL-6 and TNF-α in all investigated groups including control.
Keywords:
hypothyroidism
non-toxic goiter
aggregation
platelet
immuncytokines
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