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NOOTROPICACTIVITY OF BRAIN-DERIVED NEUROTROPHIC FACTOR DIPEPTIDE MIMETIC GSB-106

DOI: https://doi.org/10.29296/25877313-2020-01-03
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1
Year: 
2020

P.Yu. Povarnina Ph.D. (Biol.), V.V. Zakusov Research Institute of Pharmacology (Moscow) E-mail: povarnina@gmail.com D.M. Nikiforov Ph.D. (Biol.), V.V. Zakusov Research Institute of Pharmacology (Moscow) S.O. Kotelnikova Ph.D. (Biol.), V.V. Zakusov Research Institute of Pharmacology (Moscow) V.A. Kraineva Ph.D. (Biol.), V.V. Zakusov Research Institute of Pharmacology (Moscow) T.A. Guydasheva Dr.Sc. (Biol.), Professor, V.V. Zakusov Research Institute of Pharmacology (Moscow) S.B. Seredenin Dr.Sc. (Med.), Professor, V.V. Zakusov Research Institute of Pharmacology (Moscow)

A potential antidepressant based on the BDNF loop 4 dipeptide mimetic GSB-106, bis-(N-monosuccinyl-L-seryl-L-lysine) hexamethylenediamide, is de-veloping at the V.V. Zakusov Research Institute of Pharmacology.It is well known that depression is often accompanied by cognitive impairment. The aim of this investigation was to study the nootropic activity of GSB-106. The effect of GSB-106 dipeptide on memory was studied upon subchronicintra-peritoneal (ip) administration to unbred male ratsusing novel object recognition testand passive avoidance reflex amnesia caused by maximum elec-troshock (MES).GSB-106 was administered at a dose of 0.1 mg/kg (ip) for 14 days before the object recognition test and at doses of 0.1 and 1.0 mg/kg (ip) for 5 days before passive avoidance reaction training. It was found that GSB-106 at a dose of 0.1 mg / kg improves working memory in the novel object recognition test, increasing the relative time of investigation of an unfamiliar object, and at a dose of 1.0 mg / kg shows a pronounced antiam-nestic activity with a therapeutic effect of about 60% in the passive avoidance reaction test with amnesia caused by MES. Thus, the dipeptide mimetic of the BDNF loop 4 GSB-106 exhibits nootropic activity.
Keywords: 
dipeptide mimetic
BDNF
GSB-106
nootropic activity
passive avoidance test
novel object recognition test

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